SLENDERIIX XCELER8

Slenderiiz Weight Management Program with Slenderiix Xceler8

[Slenderiiz Clean Eating - Easy Recipes for a Healthy Life]

[Slenderiiz, Drop to Drop - Lose Weight 2x Faster - Click Here]

REAL PEOPLE. REAL RESULTS.

Weight Loss Disclaimer: Always check with your healthcare professional before starting any weight loss program, and before discontinuing or reducing dosage of prescription medications.A consumer study showed that individuals lost an average of 13 to 15 pounds in 28days on the Slenderiiz™ program. Results may vary depending on diet and exercise.

The Ingredients in Slenderiix Xceler8

SLENDERIIZ BOTTLE LABEL

XCELER8 BOTTLE LABEL

Losing Weight With Slenderiiz Is Easy

Belly Fat is the most difficult fat to lose. Some diets and pills focus directly on stubborn belly fat. The fat stored around the belly is only used by the body during starvation or pregnancy. If you are a man… the only option you have is starvation if you want to get that six-pack back.

Fortunately, Slenderiiz makes losing belly fat easy. Just take the drops, follow the system, and you will see results like you have never seen before with any other program. You could lose up to ¾ pound per day.

Are Slenderiix and Xceler8 Safe?

Yes, they are! Slenderiiz is 100% homeopathic, 100% hormone-free, and manufactured in the USA in an FDA-approved homeopathic facility. It contains no drugs or synthetic chemicals.

Slenderiiz employs a modern approach to homeopathy, blending individual proven remedies into one cohesive formula to effectively address all imbalances contributing to abnormal weight gain. Contributing factors include hormonal responses to excessive stress—whether dietary, emotional, or environmental; capacity for cellular detoxification, neurotransmitter communication, stable hunger patterns, and freedom from addictive behaviors, all of which contribute to systemic flushing of abnormal fat stores when balanced. Slenderiiz was successfully tested in over 10,000 patients before ARIIX obtained exclusivity and began in-house beta testing and clinical observation in 2011.

But typical “diets” fail because they are based on reducing calories from the same low-nutrition foods that made people unhealthy to begin with. They do not consider the toxicity of today’s environment and how these burdens create a greater nutritional need than ever before.

Abnormal fat storage, which results from a suppressed metabolism, is a disease of deficiency and coexistent toxicity. The only way to create and sustain a slender body for life is through a program that addresses nutritional rebalancing and systemic detoxification simultaneously.

“One of the most important things is learning that we are not genetic winners or losers; we are all choosers.”

Dr. Marlisa Hurt PhD
Anti-Aging Medicine

Q: Are any sweeteners besides Stevia approved for the Slenderiiz Program?
A: For the best results, we recommend only using Stevia or Luo Han Guo sweetener while on the Slenderiiz Program. Both liquid and powdered Stevia are acceptable. Luo Han Guo sweetener, derived from Monk fruit, is also ideal.

Q: Can I take Slenderiiz while on chemotherapy?
A: We do not condone the use of weight loss products during such a stressful time on the body.

Q: Can someone who is going through any surgery still be on Slenderiiz and supplementation?
A: Yes, except for Magnical-D should not be taken due to the potassium. As always, PLEASE REFER TO YOUR PHYSICIAN.

Q: Does birth control affect Slenderiiz's results?
A: Please refer to your physician.

Q: Does Slenderiix or Xceler8 affect blood pressure?
A: We have never known Slenderiix Xceler8 to affect blood pressure.

Q: How do I use the Xceler8 complex with Slenderiix?
A: Slenderiix is a homeopathic synergistic blend of ingredients that work together to help you lose weight fast. Xceler8 helps ensure maximum effectiveness when used with Slenderiix Drops. It does this in 3 ways. First, it optimizes the absorption of everything you eat and drink, including the Slenderiix drops. This ensures you receive more nutrients from the food you eat. Second, it supports increased blood circulation throughout the body. The boosted blood flow helps you and your joints feel better, primarily through the extremities. Third, you will experience increased energy.

Q: How does Slenderiix work?
A: It is theorized that Slenderiix causes your hypothalamus to mobilize fat out of your body's fat storage areas and makes it available.

There are three types of fat found in your body.
Structured Fat: Found between the joints and organs
Normal Fat: Located throughout the body; used to meet the body's daily nutritional needs.
Abnormal Fat: Deposits causing obesity; only drawn upon during starvation and pregnancy. By restricting your caloric intake, the body can only draw upon the structural and normal fat reserves. That is why starvation diets alone do not work and cause people to gain weight. The body compensates for low food intake by beginning to store more fat.

Q: How long do I leave the Slenderiix drops under my tongue, and what do I do afterward?
A: It is best to leave the Homeopathic Slenderiix Drops under your tongue for 10 seconds. After that, you can simply swallow the liquid. It's also important not to have anything to eat or drink 10 minutes before or after you take the drops.

Q: How long do Slenderiix Xceler8 drops last after opening?
A: Slenderiix drops do not expire if kept out of the sun. Xceler8 drops expire one year after opening.

Q: How much weight will I lose on average with the Slenderiiz Program?
A: Weight loss varies from person to person, but on average, most people will lose between 13 and 15 pounds within 28 days on the Slenderiiz Program.

Q: Is honey approved for the Slenderiiz Program?
A: No. The only two approved sweetener options are Stevia and Luo Han Guo sweetener.

Q: Is olive oil considered a healthy fat while on the Slenderiiz Program?
A: Vegetable oils are only recommended on the Slenderiiz Program if they are raw and unheated. For optimal results, we recommend coconut oil while in the program. Our favorite coconut oil is from Tropical Traditions because it is triple distilled and flavorless, making it suitable for raw consumption and cooking.

Q: Is Slenderiix recommended for a recovering alcoholic or someone who has gone through an AA program?
A: Unfortunately, we can't make this very personal decision for you. The amount of alcohol in Slenderiix is so minimal that it won't even be detected in an alcohol screening test. The alcohol content in an entire bottle of Slenderiix is approximately the same as the amount you would get if you ate two ripe bananas.

Q: Is Slenderiiz suitable for an asthmatic?
A: Yes, it is; however, you should always seek the approval of your healthcare practitioner.

Q: What are the common side effects of the Slenderiiz Program?
A: While side effects are rare, common ones include bloating, diarrhea, constipation, stomach upset, and gas. These are all natural side effects of introducing a new diet to your digestive system.

Q: What are the side effects of the Slenderiiz program?
A: There are no known side effects associated with using Slenderiix Xceler8. However, as with any weight loss program, you should consult your doctor before beginning.

Q: What can I expect when starting the Slenderiiz program?
A: You can expect to be hungry during the diet for the first few days. After about 48 hours, the Slenderiix Xceler8 Drops begin to curb your hunger and release fat stores to help feed your body. Factors that ensure faster weight loss include making fibrous vegetables like broccoli, cauliflower, and Brussels sprouts part of your lunch and dinner meals. Fiber and water intake are essential to your success with this program.

Q: What do I do if I hit a plateau?
A: It is expected to experience a plateau for 2 to 5 days (where weight loss stops). If it persists past six days, you need to do two of three things:

Option 1: For one full day, eat only six apples (and take your Slenderiix Xceler8 drops). Drink as much water as you need, but eat only six apples.

Option 2: For one full day, eat nothing but protein (and Slenderiix Xceler8 drops). Again, eat nothing but protein and water.

Option 3: Drink 3 PureNourish shakes daily with two apples and plenty of water.

Q: What grain is the grain alcohol from which Slenderiiz is made?
A: The grain alcohol in Slenderiiz is made from potatoes.

Q: What if I need to cheat? What can I do without completely falling apart?
A: This is one of our most asked questions. If you are going to cheat, then cheat with lean proteins or green vegetables. Please don't eat sweets, ice cream, or other simple sugars. If you do, it will set you back 3 to 4 days. You are not going to gain 5 pounds suddenly. However, you will not lose weight for 3 to 4 days. We prefer not to cheat, but if you do, be innovative. Whatever you do with this, do it in moderation, and don't let it set you so far back that you give up on the diet altogether. Remember, you will not meet your weight loss goal if you quit on the diet. But cheating once or twice will not derail you.

Q: What if I want to exercise while following the Slenderiiz program?
A: This diet is highly flexible. If you would like to exercise, you need to offset calories burned with increased consumption. For example, if you run and burn 300 calories, you must balance that out by consuming 75% of those 300 calories (or an additional 225 calories). But you may only eat the approved proteins and vegetables. No extra fruit. It is important to note that vigorous exercise will slow your weight loss. You will lose inches, but your weight loss will be slower.

Q: What if I want fewer calories on the Slenderiiz program?
A: Our program is built on 1250 calories, but you may take in fewer calories at your sole discretion to increase your weight loss. We suggest you discuss this with your doctor before beginning any new weight loss program.

Q: What preparations are required for the Slenderiiz program?
A: The most important preparation you can do is to decide to follow the diet mentally. It would be best to stay on the diet for it to work. The great news is that in 30 days, you may be a new you.

Q: What should I do if I get a headache?
A: People can sometimes get headaches following a lower-calorie diet. You can drink an electrolyte-rich beverage with zero or low calories to alleviate this. Coconut water is a great choice.

Q: What should I do if I've had symptoms for over two weeks?
A: There is a minimal possibility that you may have an allergy or intolerance to a specific ingredient in the product. You should consider discontinuing use and consult your physician.

Q: What would you advise a customer who wants Slenderiiz but doesn't assimilate B vitamins?
A: In this case, the customer could consider taking the Slenderiix and giving the Xceler8 to a friend.

Q: Why am I constipated while on the Slenderiiz Program?
A: Constipation is prevalent among people intentionally losing weight. Just like your bowel movements are often disrupted during an irregular routine such as travel, it can also momentarily lock up as a natural reaction to your new diet, causing constipation. Also, constipation from switching to a high-protein diet could mean you aren't getting enough fiber. We suggest ensuring you drink enough fluids, increasing walking to one hour daily to get the body moving, chewing foods thoroughly, and increasing fiber intake from vegetables. Also, liquids dilute your digestive juices, making it harder for your body to digest your food, so save fluid intake until after you've eaten your meal. Your body should adjust to your new diet within 1-2 weeks, alleviating symptoms. If not, please get in touch with your physician. (http://www.webmd.com/digestive-disorders/digestive-diseases-constipation)

Q: Why am I getting a headache while on the Slenderiiz Program?
A: According to the National Headache Foundation, 30% of headaches are related to diet-related issues. Therefore, when you're rapidly losing weight, a common side effect is frequent headaches. Cutting sugar, caffeine, salt, and fat can cause your headache. Another likely headache trigger is dehydration, so increase your water intake. Your body should adjust to your new diet within 1-2 weeks, alleviating symptoms. If not, please get in touch with your physician. (http://www.rd.com/slideshows/headache-and-weight-loss-what-your-body-is-telling-you/#slideshow=slide3)

Q: Why am I having stomach discomfort?
A: You are likely experiencing a diet of this nature for the first time. Any time you alter your diet, typical side effects such as stomach discomfort, diarrhea, and constipation can occur. Please don't worry- this is very common. You can diminish this symptom by decreasing the serving size of PureNourish. Your body should naturally adjust to your new diet within 1-2 weeks, alleviating symptoms. If not, please get in touch with your physician.

Q: Why am I losing my hair while on the Slenderiiz Program?
A: Hair and weight loss often go hand-in-hand because hair follicles are susceptible to external stresses. Many people experience hair loss after dropping just 15 pounds, which can continue for 3-6 months after losing the weight. The hair will grow back on its own.

Q: Why am I sleepless while taking Slenderiiz?
A: If you use Xceler8 at night, the product's B vitamins and green tea extract could disrupt your sleep. You could also eat too late at night, making your body spend energy on digestion while trying to sleep. Try increasing your morning and afternoon serving of Xceler8 to avoid taking it at night and eat dinner earlier in the evening. If you're taking Rejuveniix, don't use it at night. Give yourself 5-6 hours between taking it and going to sleep.

Q: Why aren’t bananas on the Slenderiiz Approved Foods List?
A: Bananas are high glycemic, and we want to control blood sugars while losing weight.

Q: Why can’t you eat starchy carbs such as rice, pasta, and bread on Slenderiiz?
A: These types of food have a high glycemic index, which means that they raise blood sugar levels. The Slenderiix program is designed to control blood sugar levels.

Q: Why do I feel bloated when starting the Slenderiiz Program?
A: The pea protein in PureNourish is the safest protein available, with even fewer side effects than whey, though it occasionally causes bloating. You can relieve this symptom by decreasing your serving amount. Your body should naturally adjust to your new diet within 1-2 weeks, alleviating symptoms. If not, please get in touch with your physician.

Q: Why do I have diarrhea while on the Slenderiiz Program?
A: Diarrhea is prevalent, even among non-dieting, healthy adults. When you introduce new foods to your body, particularly leafy greens, you can expect an adjustment period of 1-2 weeks for your digestive system to right itself and symptoms to ease.

PureNourish also introduces healthy bacteria to your digestive system, which can cause loose stools. Reduce your intake if you use more than one serving of PureNourish daily. Your body should naturally adjust to your new diet within 1-2 weeks, alleviating symptoms. If not, please get in touch with your physician.

Q: Why is alcohol used in Slenderiix?
A: Slenderiix is a homeopathic product that uses alcohol as a safe preservative. Alcohol also acts as an absorption agent, increasing the uptake of ingredients into the bloodstream.

Q: Why have I stopped losing weight on the Slenderiiz Program?
A: There are several reasons your weight loss may have plateaued:

1. You're constipated. This is most often why people on the Slenderiiz Program stop losing weight.
2. You're dehydrated. This will reduce your weight loss efforts, so increase your water consumption.
3. Sugar is sneaking into your diet. It can be found in the most unlikely places, like salad dressings, sauces, and beverages. Make sure you eliminate all sugar from your diet, including dining out.
4. Release of toxins from fat stores. When losing drastic weight, your body might work against you, holding onto toxins. This can cause rebound weight gain. Make sure to detoxify by taking Restoriix while on the Slenderiiz Program.

Q: Why is Slenderiiz the best choice?
A: There are so many reasons! Here are the top four:

1. Slenderiix is manufactured in the USA by an FDA-approved facility.
2. Slenderiix gives you a Hormone-Free formula to maximize your diet results by providing a 100% homeopathic formula.
3. Slenderiix is a complete formula. It is not a watered-down version of amino acids.
4. Slenderiix uses a multi-phased approach combined with a 1250-calorie diet to promote sustainable weight loss. Keeping you at your ideal weight is our mantra.

Q: Why the 1250-calorie diet on the Slenderiiz program?
A: Because you only consume 1250 calories, Slenderiix signals your hypothalamus to mobilize fat out of your body's fat storage areas, making it available to burn as you go about your daily activities.

Q: Will decreasing the amount of product I take affect my weight loss results?
A: You will still lose weight even if you decrease the amount of product you're taking, but it will likely be less.

Q: Will taking Restoriix change the effectiveness of Slenderiix?
A: You can take the two products together. However, for optimal results, Restoriix ideally should be taken on an empty stomach.

Q: Would it be okay to carry Slenderiiz in plastic bottles?
A: We recommend leaving it in glass bottles. This keeps the product unaltered, as plastic can leach chemicals, especially when using alcohol.


*SOURCE: https://ariix.zendesk.com/

Slenderiiz Clinical Pack

Abstract

The placebo-controlled study evaluates subjects’ hormonal, physiological, and physical responses to a patented blend of homeopathic ingredients (herein referred to as “Slenderiix”), in conjunction with the methyl-form of B vitamins compounded with adaptogenic herbs (hereinafter referred to as Xceler8, and when employed compatibly, are known as The Slenderiiz Weight Loss Program); therapeutic nutrition, optimal hydration from purified water; appropriate nutritional supplementation for optimal metabolism; a detoxifying restorative blend of zeolite minerals and nutrient dense green super-foods, (hereinafter referred to as “Restoriix”); and a whole food antioxidant-based energy and focus formula for enhanced dopamine utilization and neurotransmitter communication, (hereinafter referred to as Rejuveniix).

Greater improvement in the rate of loss and the total amount of loss was attained related to whether subjects consumed Slenderiiz products along with foundational Nutritional Supplements, detoxified with Restoriix, and added Rejuveniix to all of the above.

Visceral adipose fat tissue measures and serum inflammatory markers that indicate health risks were improved. Serum measures related to cholesterol and triglycerides were significantly improved. The cardiac inflammation metric HS-CRP was significantly reduced, and blood sugar levels related to glucose, HbA1C, and insulin were also improved.

Finally, the subjects' physical, psychological, and emotional changes were observed. Subjects losing weight at an increased rate noted increased enthusiasm, energy, and confidence. The psychological impact of being empowered with the knowledge and ability to create a powerfully positive metabolic shift, especially within such a short period of time, was transformational for all test subjects taking ARIIX products rather than calorie reduction alone.

Introduction

Finding a product that enhances the effectiveness of healthy lifestyle choices to induce fat loss could significantly reduce the health complications, medical costs, and death rates associated with obesity. This study attempts to examine such a product.

These latest figures from the Centers for Disease Control (CDC) demonstrate that obesity continues to be a significant public health problem. In 2008, medical costs associated with obesity were estimated at $147 billion. (1) The average annualized costs for being overweight have been estimated at $8,365 for obese women and $6,518 for obese men. (13)

An analysis estimated the 2007 obesity prevalence among adults by state from self-reported weight and height data from the Behavioral Risk Factor Surveillance System (BRFSS) found that state-specific obesity prevalence ranged from 18.7% to 32.0%.

Among 2007 BRFSS respondents, 25.6% were obese, 26.4% of men and 24.8% of women were obese. The obesity prevalence ranged from 19.1% for men and women aged 18-29 years to 31.7% and 30.2%, respectively, for men and women aged 50-59 years. The obesity prevalence was higher in the South (27.3%) and Midwest (26.5%) and lower in the Northeast (24.4%) and West (23.1%). (2)

Curbing obesity by limiting calories alone is often ineffective due to hormonal protective responses. Too low of a daily caloric intake over a sustained period of time can sabotage long-term weight loss by suppressing metabolism, possibly causing the body to lock up fat stores for future survival. Hence, there is often a leveling of the rate at which a low-calorie diet alone will reduce weight and stabilize to an ideal weight long term. In order to reduce the risk of obesity-related secondary diseases, complete lifestyle intervention is necessary, which addresses nutrient-dense nutrition, thereby opening the pathways for optimal metabolism and detoxification.

Within the last five years, the emerging field of epigenetic research has shown that the hormonal implications of glycemic index values, glycemic load values, and toxic chemical burdens from air, water, and food are critically linked to whether or not an individual will gain or lose weight—even in the presence of a calorie deficit. Epigenetics is the study of gene regulation, manipulation, and the resulting expression of health or disease.

This science is based on the study of cellular “memory” and biological responses involving chromatin modification or remodeling due to variations from environmental input from food, water, air, skin, emotional stress, etc, all factors other than those recorded within or prompted by DNA. Current theory in Epigenetic Research is that chronic degenerative disease is not due to genetic predisposition for the most part, but rather 85-95% of environmental input is the cause of these diseases, and the (estimated 5-15%) remaining risk factor is related to gene inscription. This suggests that genes have very little innate bearing on daily cell health when compared to other factors.

Due to the epigenetic and psychoneuroendocrinological observations of the common factors of nutrient deficiency and coexistant presence of toxic load on catalyzing a default mode of human fat storage, this study was created to determine if exceptional fat loss could be observed in conditions of nutrient density through calorie-limited ideal food choices, appropriate nutritional supplementation, appropriate hydration/detoxification with purified water, and cellular detoxification and neurotransmitter rebalancing by means of pharmacological TID dosing with a patented sublingual homeopathic catalyst, and methylcobalamin (B12) compounded with a proprietary blend of adaptogenic herbs, hereinafter referred to as Slenderiix Xceler8.

Slenderiix Homeopathic Tincture

Homeopathy is a 200-year-old medical discipline with a proven safety and efficacy track record. Due to the foundational principles of using natural substances in an infinitesimal dose within a diagnostic method of “like curing like,” there are no known contraindications to pharmaceutical drugs. Homeopathic preparations have been regulated under the law since the inception of the Food, Drug, and Cosmetic Act, authored by Senator Royal Copeland, M.D., a practicing homeopath, in 1938. (40)

Homeopathic preparations are recognized as drugs under the Federal Food, Drug, and Cosmetic Act (“FD&C Act”), 21 U.S.C. § 201 et seq. Section 201(g)(1) of the FD&C Act, 21 U.S.C. § 321(g)(1), which defines the term “drug” as “articles recognized in the official United States Pharmacopoeia, official Homeopathic Pharmacopoeia of the United States, or official National Formulary, (i) or any supplement to any of them . . . .” (40)

Slenderiix employs a modernized approach to homeopathy, blending individual time-proven remedies into one cohesive formula to effectively address all imbalances that contribute to today’s epidemic of abnormal weight gain.

Contributing factors include hormonal responses to excessive stress—whether dietary, emotional, or environmental; capacity for cellular detoxification, neurotransmitter communication, stable hunger patterns, and freedom from addictive behaviors. When balance is achieved, all of these contribute to systemic flushing of abnormal fat stores. Slenderiix was successfully tested in over 10,000 patients prior to ARIIX obtaining exclusivity and beginning in-house beta testing and clinical observation.

The Materia Medica catalogs all methodology within the discipline of homeopathy and references the functions of each remedy as excerpted below:

Ammonium Bromatum: Indicated in chronic laryngeal and pharyngeal catarrh, neuralgic headaches, and obesity.

Avena Sativa: Exhibits selective action on the brain and nervous system, favorably influencing their nutritive function. Indicated in nervous exhaustion, sexual debility, and addictive morphine habit. It is the best tonic for debility after exhausting diseases and sleeplessness, especially for alcoholics. It also addresses the nervous states of many chronic female concerns.

Calcarea Carbonica: Chief action is supporting impaired nutritional metabolism, the glands, skin, and bones are most instrumental in changes evidenced. Needed for increased local and general perspiration [for normal systemic detoxification]… nausea, acidosis, and breathlessness, a jaded state—mental or physical, due to overwork.

Fucus Vesiculosis: A remedy for obesity and non-toxic goiter, thyroid enlargement in obese patients. Digestion is enhanced, normalizing obstinate constipation, and flatulence is diminished.

Graphites: An anti-psoric carbon, most active in stout individuals with fairer complexions, with tendencies toward skin affections and constipation, excess fat storage with a tendency to obesity, chronic low body temperature, with delayed menstrual history, who become cold easily, may suffer anæmia with redness of the face, a tendency toward inflammation of the pylorus or duodenal illness.

Ignatia Amara: One of the chief remedies for hysteria. It is specially adapted to the nervous temperament of women who are of sensitive, easily excited nature, quick to react, rapid in execution and change of mental and physical condition, nervous, apprehensive, rigid, trembling who suffer acutely with mental or physical stress.

Lycopodium Clavatum: Supports conditions where ailments are gradually developing with functional weakening regarding digestion, liver function, predisposition to uric acid metabolism, intolerance to cold, and muscular strength. Marked regulating influence upon the glandular (sebaceous) secretions, those benefitting from Lycopodium lack vital heat [indicating lower than optimal metabolism] and have poor circulation, with cold extremities, acute temporary pains, and sensitivity to noise and odors.

Nux Vomica: Typical individuals calmed by Nux are thin, spare, quick, active, nervous, and irritable. Especially adapted to digestive disturbances, flatulent abdominal distention, and hypochondrial states, Nux may also address conditions such as ravenous hunger, sour taste in mouth, nausea in the morning after eating, weight and pain in the stomach, and feeling worse after eating.

Sulfuricum Acidum: This remedy supports those with chronic acidosis and digestive tract abnormalities and may be evidenced by a craving for stimulants. Tremor and weakness, hurried temperament, hot flashes followed by perspiration with trembling, diminished rate of healing after medical procedures, gastralgia, and hypochlorhydria.

Thyroidinum: Exercises have a general regulating influence over the mechanism of the organs of nutrition, growth, and development. Used in psoriasis, tachycardia, arrested development in children, linked to improvement in memory, goiter, obesity, mammary tumors, uterine fibroids, and fibroid tumors of the breast. Addresses the sensation of faintness and nausea, extreme weakness and hunger, sensitivity to cold, and symptoms of Hypothyroidism after acute diseases, i.e., weakness, easy fatigue, and weak pulse. (41)

     i. Since the passage of the FD&C Act, the United States Pharmacopoeia and the National Formulary have merged.

     ii. As noted, the United States Pharmacopoeia and the National Formulary have merged to create only two “official” compendia.

     iii. Homeopathic drugs are also covered by the Medicare-Medicaid Statute, 42 U.S.C. § 1395x (t), which defines  drugs to “include only such drugs . . . as are included (or approved for inclusion) in the United States Pharmacopoeia, the National Formulary or the United States Homeopathic Pharmacopoeia.”

Xceler8: Metabolism and Energy Support

The coenzyme form of B12, known as methylcobalamin, provides the foundational structure of the Xceler8 product. This methyl-donating form of B12 is superior to analog chemical copies of B12 that are typically used in pharmaceutical drugs, inexpensive vitamins, and “enriched” processed foods. (43) Various methyl donors are required in the body to chemically transform chemical substances into usable forms for nutritive function. Methyl donors are also used to neutralize destructive byproducts, such as homocysteine, into benign substances that would otherwise contribute to disease. Methylcobalamin is the only form of B12 that is able to dispose of homocysteine through methylation and enables the production of SAMe (S-adenosyl methionine), the most important methyl donor for adequate glutathione levels possible. Adequate glutathione synthesis in the body is the hallmark of a strong immune system and high-functioning metabolism. (44)

Cyanocobalamin is a chemically derived synthetic or analog vitamin B. The B vitamin portion is cleaved into a cyanide molecule, which requires the presence of a methyl donor to be broken down by the liver to split off the (toxic) cyanide component, allowing the remainder to be converted to the biologically active form of methyl B12. This synthetic cyanocobalamin B12 is typically 100 times cheaper than methylcobalamin and contributes to system-wide methyl donor depletion, which can cause a relative shift in homocysteine metabolism, increasing the significant risk of heart disease, neurological degeneration and measurable age-related brain shrinkage.

“Homocysteine tends to accumulate in the body whenever (methyl or usable) B12 gets deficient. Homocysteine accumulation has been linked with increased risk of cardiovascular disease, chronic fatigue syndrome/fibromyalgia, multiple sclerosis, and Alzheimer’s Dementia, among other conditions.” (44)

An Oxford University study published in The Journal of Neurology reported an estimated 40% of the population is deficient in B12. (45) B12 deficiency is so widespread because of commonly used pharmaceutical drugs like estrogen-containing birth control pills, antacids— including excessive calcium supplementation, antibiotics, anti-cancer drugs, anti-psychotics, and anti-diabetic medications. All of these directly cause B12 depletion. Without adequate B vitamins to suspend the bile salts in the liver, fat-soluble nutrients are not able to be assimilated, resulting in compromised metabolic, neurological, and immune function.

Subjects in a study reported in Neuropsychopharmacology comparing the effects of methylcobalamin to cyanocobalamin reported remarkable results in only one week of supplementation. Methyl B12 users reported reduced sleep time, increased sleep quality, feeling more well-rested upon rising, increased daytime energy, and ability to concentrate. (46) Restoring appropriate levels of B12 supports healthy energy levels and excellent neurological performance. (43) Biotin is a coenzyme and B vitamin that, when combined with chromium, has been shown to reverse insulin resistance and support healthy blood sugar levels. Even when tested in isolation, biotin plays a significant role in several key metabolic functions in digestion and blood sugar regulation. Biotin supports the integumentary (skin) and nervous systems by facilitating the repair of nerve damage due to type 2 diabetes, and fosters improved glycemic impact on these systems. (47)

Rhodiola Rosea and Ashwagandha are adaptogenic herbs used traditionally in both Chinese and Ayurvedic Medicine. Adaptogens are defined by their ability to have a normalizing effect on the body, allowing the individual to become more resilient to chronic stressors, whether physical or emotional. Adaptogens are non-toxic plant-based therapies that normalize physiological functions that have been disturbed by chronic stress. These work through the correction of balance to the neuroendocrine and immune systems. (42) Adaptogens have been used successfully to treat a milieu of chronic health conditions for over 100 years, contributing to the current theory that stress is the number one contributor that drives the pathology of all diseases. Specifically, Rhodiola has been shown to prevent the excess release of cortisol and adrenaline in response to stress, also blunting the increase in cholesterol and triglycerides typically triggered in response to stress. Rhodiola helps to transport serotonin precursors, reducing depression, and increases body fat-to-muscle ratio by mobilizing fatty acid stores during exercise, supporting increased fat burning. (42) Ashwagandha has been used successfully in both India and China as an aphrodisiac to treat insomnia, anxiety, fibromyalgia, and arthritis and to promote emotional balance in cases of depression and mental or physical fatigue. (42)

Appropriate Supplementation: Vitamins and Minerals

Every ingredient in the Optimals is certified as of non-GMO origin, and these products are manufactured in an OTC facility, certified for efficacy, purity, and potency by NSF, GMP, and the FDA, providing exacting standards of quality assurance, dependability of consistency, and purity. Studies have concluded that supplements containing natural food nutrient complexes are better than supplements containing only isolates. [11][12]

Getting appropriate levels of vitamins and minerals every day is essential to not only a high-functioning metabolism, but these can be the critical differentiators between vital health and the simple absence of an illness. Because most people in the world are deficient in one or more of the 40 vitamins, minerals, and other essential biochemical nutrients necessary every day for minimal survival, and the human body was created with an innate ability to adapt to amazing variables and still survive, we observe most people today experience life, not in a state of vital health, but fluctuating on the continuum between the absence of illness and experiencing illness.

Most individuals are grossly deficient in the critical “Metabolic Supportive Nutrients,” which are crucial to appropriate blood sugar control, stress responses, methylation of foods into usable forms that can actually nourish the body at the cellular level, and control every enzyme reaction from fluid regulation to neurotransmitter production. As a nation, Americans are over-fed and yet undernourished and chronically stressed. This chronic state of deficiency results in a downshifting of the metabolism to attempt to spare what nutrient resources are remaining. This is most evidenced by mental sluggishness, poor digestion, daytime fatigue, poor sleep, chronic aches and pains due to inflammation, and cravings that are not satisfied by food. As the brain signals the body to input more nutrients to try to satisfy these vital deficiencies, and people answer these signals with low-nutrient convenience foods—notoriously high in sugar, starch, vegetable oils, chemical additives, and stimulants—metabolism continues to down-regulate and disease breeds at a faster rate.

Bruce Ames, Ph.D., professor of biochemistry and molecular biology at the University of California, Berkeley, analyzed over a hundred chronic degenerative diseases that are triggered by nutrient deficiencies. These symptoms in the early stages are typically identified by traditional medicine as “typical signs of aging,” but with obesity and other metabolic, chronic inflammatory, and autoimmune diseases becoming more common in adolescents and children, his revolutionary analysis, “The Triage Theory ”(1, 2) has not come too soon. In his observations, he found that over 50 enzymes within the body are completely dependent upon daily intake of adequate amounts of vitamins, minerals, and essential fatty acids in order to be catalyzed. Without consistent, adequate levels of these three complexes every day, it is impossible for the body’s enzymes to begin their work and for humans to experience vital health and optimal metabolism.

These nutrients, which have to be taken in daily, a minimum of twice a day, to replenish fuel necessary for routine cellular renewal throughout the day, are the critical factors that determine whether human genes are prompted to express health or disease. Dr. Ames found that a deficiency of any one of this array of critical micronutrients posed a threat of oxidative stress damage to cellular integrity and metabolism that was equal to and, in some circumstances, greater than 100 times the known damaging effects of radiation! (1,2,3,6) It is established that if individual cells within the organs of the body have a low metabolism due to low fuel levels, then these organs will also be functioning at a lower-than-optimal level. This means the entire body is then operating in survival mode of a low-functioning metabolism while usually experiencing a default of fat storage to conserve nutrient resources and creeping closer to chronic degenerative disease.

Continuing his work at the Nutrition and Metabolism Center, Children’s Hospital and Research Institute, Oakland, CA, Dr. Ames observes what he describes as a shift within the body toward short-term survival gene expression as a coping mechanism in times of low nutrient intake. This shifting into survival mode simultaneously requires sacrificing the expression of genes that produce long-term health. (4) This means that if we see individuals whose bodies are downshifting and accommodating to low nutrient intake by storing fat abnormally to spare nutrient reserves—this single indicator—belly fat, is enough to indicate life-shortening inflammatory diseases are not far down the timeline if these nutritional deficiencies are not quickly remediated with therapeutic dosing of these essential nutrients. (5,6) Dr. Ames also postulates that micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neurological decline but would leave critical functions like ATP production intact.(7)

The National Health and Nutrition Examination Surveys (NHANES) have long reported that the food intake of the following groups of people in the United States does not provide adequate nutrition from all 40 essential nutrients for adequate health: the poor, teenagers, menstruating women, the obese, and the elderly. According to the Estimated Average Requirement (EAR) [see Table 1], opinion has now shifted that micronutrient levels from food are probably not adequate for anyone else to express optimal health without disease. (7)

Westernized diets are typically characterized by excessive calories from starchy carbohydrates, processed oils, and below micronutrient thresholds determined essential for minimal health. Dr. Ames notes that this low consumption of micronutrients accompanied by calorie excess may be the norm for those who are overweight and obese and contributes to the deadly diseases associated with obesity. “Significant chronic disruption may occur when consumption of micronutrients is below the current RDA (8) but above the level that causes acute symptoms. When one component of the metabolic network is inadequate, there may be a variety of repercussions in metabolism, including acceleration of degenerative diseases.”(7)

Due to these findings, high-quality multivitamin supplementation is recommended as a low-cost preventative intervention in combination with the healthiest possible food choices. This is the best low-cost adjunctive for optimal health and reducing the risk of common age-related diseases associated with obesity and, ultimately, death by secondary diseases of CHD and cancer.It is now generally maintained that inflammation is the root cause of chronic degenerative conditions. Systemic inflammation is indicated by abnormal fat storage, swelling, chronic joint and bone pain, allergies, asthma, and headaches in the early stages, but also heart disease, cancer, and neurological diseases, as the above-mentioned earlier symptoms continue unchecked.ARIIX Restoriix is a blend of zeolite, chia seeds, and nutrient-dense organic spirulina, chlorella, and chlorophyll. Zeolites are highly alkaline minerals that contain large structural vacancies and carry a negative ionic charge, giving them superior binding adhesion to positively charged pathogenic toxins. The zeolite blend sourced for Restoriix is ultra-purified and certified free of lead and other contaminants common to earth-sourced minerals. The highest grade nano-sized particles provide for increased surface area adhesion of free radicals and environmental pathogens and a smooth, palatable texture. Zeolite’s magnet-like effect attracts impurities and binds them within its honeycomb-like molecular structure, preventing the resorption of toxins as they are excreted from the body through the natural process of digestion.Rejuveniix is an energy-boosting blend of low-temperature dehydrated fruit and berry extracts chosen for their wide variety of polyphenols and bioflavonoids. Effectively combined with green coffee bean extract, kava root extract, and the amino acid l-theanine, this formula has been observed to provide increased mental clarity, stamina, and focus. A unique extraction process leaves exceptionally high levels of beneficial antioxidant levels intact while producing a product that contains no fructose.Twenty-three individuals were chosen for the initial study: three men and 20 females ranging in age from 21 to 75. Individuals were selected on the basis of commitment to completing the 12-week course. Subjects were selected due in part to a desire for weight loss, with at least 12 to as much as 120 pounds to lose.Subjects were required to maintain compliance for 12 weeks with a specific nutritionally dense diet, appropriate supplementation, adequate fluid intake, simple exercise, and detoxification and stress management techniques. Examples included keeping a food journal, exercising, personal contact, accountability, and counsel.Subjects receiving Nutrifii Nutritional supplements of Vitamins, Minerals, Restoriix, and/or Rejuveniix were to take them as directed on the product label. Omega-Q was given, as noted above, in a dose that is double the label guidelines. All subjects were required to take 15 drops of Slenderiix under the tongue 10 minutes before each meal. Additionally, subjects took 15 drops of Xceler8 under the tongue with breakfast and lunch. Subjects not receiving either Slenderiix Xceler8 were given a placebo.Beyond the diet, subjects were required to drink a minimum of 50% of their respective body weight of water in ounces daily. Regardless of weight, 100 ounces was the minimum amount of water for each subject each day, with no maximum limit.Since subjects were classified into four equal groups (n=5), an ANOVA was conducted to determine significance across groups. Even given the small sample size created by the factorial design, results show that significant differences existed between groups (F ratio 14.2 p<.01). Furthermore, all groups were found to be significantly different from no diet whatsoever (p<.0001).As the table depicts, over time, the rate of weight loss tapers off with each successive month of weight loss. 89.5% of subjects exceeded their personal targeted weight loss goal, projected at the onset of the trial.A collection of serum markers that accompany the onset of abnormal fat storage, specifically in the disproportionate deposition of visceral adipose tissue (VAT), have been associated with the pathology of insulin resistance. These blood levels have interrelated relationships in obesity-related disease pathology. Integrative physicians now understand that although individually, these lab indicators may enter the health assessment picture at different times due to biochemical individuality, certainly metabolic syndrome is continuing to worsen along with the increased inability to shed excess weight easily. Over time, the appearance of more and more of these particular serum markers continues to underscore the depth of the disease pathology that is pushing the patient closer to cardio-metabolic disorders and hormone-related cancers, our number one and two causes of death.Results of the study found that all groups statistically lost more weight than those on no weight loss regimen whatsoever. However, subjects using Slenderiiz lost just over twice as much (103.4%) weight per day (.51 lbs p/day) compared to subjects on either a 1250 calorie diet alone (.24 lbs p/day) as well as the Placebo Group (.23 lbs p/day). Subjects taking Rejuveniix in conjunction with Slenderiiz had a significantly higher (+3%) rate of weight loss.

Recognized authorities in Nutritional Medicine such as Ray Strand, M.D., Julian Whitaker, M.D., Jane Higdon, Ph.D., Michael Murray, N.D., Phyllis Balch, CNC, Nicholas Perricone, M.D. and six other known figures practicing proactive preventative nutritional medicine, were consulted to create what became known as the Blended Nutritional Standard. (9) This was constructed using 18 criteria across 48 ingredients based upon each expert’s independent input for optimal therapeutic nutrient recommendations. This blended standard has set the bar for therapeutic quality multivitamins to be measured to determine if they are prepared in adequate dosing of non-toxic and effective forms of each nutrient and if all essential nutrients are present and combined in the correct ratios one to another. The Optimals adhere to this Blended Standard.

In his book Healthy for Life, Dr. Ray Strand notes that these nutrients are needed in greater amounts than can usually be obtained by food alone. In his practice, he has personally seen a reversal of Thank You! 2 Diabetes in hundreds of patients who optimize their nutrient intake with critical levels of vitamins, minerals, and essential fatty acids and who employ the lifestyle modifications described in his Healthy for Life program. He also testifies to incredible gains in glycemic control with Type 1 Diabetics and reversing the symptoms of metabolic syndrome, thereby preventing the onset of Diabetes in thousands of people worldwide using a similar combination of appropriate supplementation, low-glycemic diet, and modest exercise. (10)

Appropriate Supplementation: Omega 3 Fatty Acids

Anti-inflammatory omega-3 fats in bio-available fish oil lower the production of prostaglandins and cytokines that trigger inflammatory responses. Clinical studies have shown that stress and depression are associated with too many inflammatory cytokines in the body, and not enough anti-inflammatory omega-3 fats are one of the foremost contributors. These two factors typically are present before abnormal fat storage begins and continues to mount along with unwanted weight.

The American Heart Association (AHA) suggests if triglycerides are high (200 mg/dL or higher) (1, 2), taking 2,000-4,000 mg of fish oil with EPA and DHA, along with dietary changes, is an effective way to reduce risk factors within a 90 day period. However, most integrative medicine specialists initially use a therapeutic loading dose with a minimum dose of 4000 mg of omega-3 oils per day, and those patients who are severely obese, depressed, or overly stressed may use much higher doses to get significant results within a 90-day time frame. (4)

Omega-Q was included as part of the foundational nutritional therapy at a dose of 4000 mg/day in an effort to produce a favorable effect on fat-burning metabolism and serum inflammatory markers within a 12-week period.

Because of the state of the environment today, many fish contain high levels of mercury, PCBs (polychlorinated biphenyls), dioxins, and other environmental toxins. These toxins concentrate in the fat stores of both the fish and the people who consume them. These fat-soluble toxins lock up fat cells and contribute to metabolic dysfunction, which is evidenced by not being able to lose weight, even when eating less and exercising more.

Many commonly available brands of fish oil supplements are “purified” with hexane, a petroleum derivative. Governing officials allow hexane residues to be present as a tradeoff for removing the heavy metal residues common to commercially available fish oils. This residual hexane in most fish oil supplements can accumulate over time and cause considerable nervous system damage. (14) Chemicals that are petroleum derivatives, in general, are suspected of causing endocrine disruption, which, over time, is associated with the development of hormone-related cancers.

ARIIX has sourced a pristine omega 3 fish oil from the only manufacturer in the world who has patented a unique low-temperature, enzyme fermentation purification process that ensures the delicate anti-inflammatory properties are not only kept fully intact but yields a superior product that is tasteless and odorless, with no unpleasant digestive after-effects that are typical of hexane-distilled or rancid fish oil products common to the shelves of vitamin chains and superstores. Enzyme purification also eliminates chemical waste byproducts, thereby reducing the environmental impact of disposing of hexane into the environment.

Appropriate Supplementation: Restoriix

Chia seeds are a superior source of vegan protein and contain over 30 nutrients. Rich in omega 3 fatty acids, containing more than three times the antioxidant capacity of blueberries, and 35% fiber by weight, chia seeds detoxify the digestive tract while providing nutrients that rebalance omega 3 to 6 ratios. Insoluble fiber scrubs intestinal walls and loosens impacted debris, while the balance of soluble fiber effectively absorbs up to twelve times its weight in fluids. (36)

Chlorophyll-rich plant foods such as chlorella and spirulina are dense in RNA proteins, which repair damaged DNA. Excessive toxic load in the body causes overproduction of free radicals, which mutates DNA, causing premature aging and accelerating disease pathology. Aging and disease are observed when DNA mutations occur within the cells, and these damaged cells reproduce. Since chlorophyll is the most known food source of RNA repair proteins, finding food sources rich in chlorophyll would inhibit DNA mutations from reproducing, according to Dr. Benjamin Frank’s work in RNA diet therapy. Dr. Frank pioneered dietary nucleic acid therapy, proving that RNA and DNA-rich supplements reverse symptoms of aging and disease and increase metabolism by increasing cellular energy (ATP) for improving intercellular communication in the body and rejuvenation, detoxification, and rapid healing. (35) Marine biologists were the first to observe the anti-aging effects of these green sea vegetables on mammals. Ocean mammals consuming large amounts of chlorophyll-rich sea vegetables, including spirulina and chlorella, have no visible signs of aging once they reach adolescence. Chlorella has more than twice the RNA density per gram of any animal protein, making it the richest natural dietary source of these detoxifying nutrients.

Spirulina is high in natural iodine, which nourishes the thyroid, protects all glandular tissues, and ultimately supports immune and metabolic functions. To improve metabolism, spirulina has been proven to improve glycemic control and dyslipidemia in Type II diabetics. (38) High in metallothionein compounds, spirulina has been shown to shield the body from radioactive isotopes by binding to them, making digestive elimination possible. Spirulina’s chemo-protective effect has shown potential for use in fighting cancer, as well as detoxifying the kidneys from overuse of antibiotics and analgesics. (37) In Russia, a study was conducted on 270 children living in highly radioactive areas, and all showed elevated IgE serum levels. This immune system inflammatory response is typically high due to allergic responses but was completely normalized in 6 weeks of feeding spirulina twice daily. (38) Spirulina’s dense array of phytonutrients, such as phytocyanin, chlorophyll, and carotenoids, contribute to the anti-inflammatory properties that nourish as they purify the body.

With an average alkalinity factor of 9.7 pH, negatively charged zeolite minerals bind unwanted toxins and reduce acid pH load simultaneously. In addition, when fat is released due to dieting, these toxic stores are freed up and circulated within the body, which can cause significant side effects if they are not completely eliminated by the digestive tract. If a toxic load overwhelms these pathways, the possibility of reabsorbing toxins can trigger a protective response of shuttling toxins into fat storage, which is represented by a weight loss plateau or rebound weight gain. Detoxification has been shown to protect against these metabolic setbacks effectively.

Appropriate Supplementation: Rejuveniix

Rejuveniix also contains a blend of acai, maqui, sea buckthorn, goji berries, mangosteen, and noni fruits. This variety of berries and fruits represents a wide range of antioxidant coverage shown to support immune function, heart health, and metabolic sufficiency. Represented within Rejuveniix are anthocyanins, xanthones, various carotenoids such as beta carotene and zeaxanthin, and plant sterols known to support heart health and detoxification and modulate oxidative stress.

2010 findings in the British Journal of Nutrition reported the therapeutic effects of berries in modulating postprandial glucose response when eaten with high glycemic foods. After consuming a meal with berries, serum levels were drawn at 15, 30, and 150 minutes and compared to blood glucose responses at the same intervals following a control meal. The results showed that consuming berries and sucrose significantly reduced the digestion/absorption of the sucrose, as evidenced by decreased serum postprandial glucose. High levels of polyphenol antioxidants in berries are attributed to this compensatory effect. (28)

The focus and energy portion of the Rejuveniix formula comes from a balance of the amino acid l-theanine, kava root extract, and green coffee bean extract. ARIIX only sources the highest quality kava root from the Republic of Vanuatu due to its superior potency and highest lactone content. This lends properties that support healthy blood pressure and the ability to relax the mind and muscles without sedative effects and loss of mental clarity.

L-theanine is sourced from green tea leaves and directly stimulates the production of alpha brain waves, allowing mental alertness (29), and also increases dopamine, “the satisfaction neurotransmitter,” allowing individuals to experience a greater sense of pleasure and fulfillment. (30)

Green Coffee Bean Extract (GBCE) is a rich source of chlorogenic acid, which has been shown to significantly affect body mass and reduce body fat when used long-term in overweight and obese subjects. (31) Green coffee bean extract has also been shown to suppress the hepatic production of triglycerides, reducing fat accumulation. (32) GCBE also works synergistically with kava kava and l-theanine, enhancing effectiveness.

In comparison, common sources of caffeine contain cafestol and other compounds associated with the negative effects of using caffeine as a stimulant. Research has shown that the combination of ingredients in Rejuveniix supports clarity of mind and a positive mental outlook by supporting neurotransmitter production, cellular communication, and healthy energy levels. (33)

Methodology

The table below provides both genders' initial weight (in pounds) and variation.

Subjects were given a 1,250-calorie, low-glycemic, low starch, functional meal plan that included a minimum amount of healthy fats from coconut oil, avocados, raw sprouted nuts, or their cold pressed oils. Because the FDA’s defined daily minimum caloric threshold for a “Low-fat Diet” is set at 30% or less of daily calories coming from fat, a minimum of 300 calories of the 1250 allowable calories were specified to be selected from healthy fat.

In addition, to quickly rebalance appropriate ratios of omega 3 fats to omega 6/9 fats within the body, subjects were required to consume 2000 IU of Omega-Q both morning and evening every day for the 12-week trial.

Because sudden excessive amounts of omega-3 fats can have a blood-thinning action, subjects were screened for contraindications, and no subjects were using anticoagulant blood-thinning medications such as Coumadin or Warfarin.

Participants simultaneously excluded all inflammation-causing omega six vegetable oils such as canola, soybean, grape seed, olive oil, and any other oil that can contribute to inflammatory cytokine production within the body and/or compete with omega 3 for conversion/uptake. An inappropriate balance of omega 3 to 6 oils blocks the pathway to healing metabolism, alters cell signaling and optimal neurotransmitter and hormone rebalance, and blunts the potential of therapeutic efficacy intended by including Omega-Q.

Subjects were instructed to choose at least twice as many non-starchy fresh vegetables as protein portions per meal to provide plenty of fiber-rich carbohydrates, which are also dense in anti-inflammatory nutrients.

All groups, except the placebo group, used the Slenderiix Xceler8 before each meal throughout the 12-week trial. With all groups, the following constants remained for the duration of the study period: food selection guidelines and daily calorie max intake, appropriate hydration to include a minimum of 5 (total based on individual weight) refills of the Puritii water bottle daily, with individual increased adjustments for weight-appropriate amounts of water, and a minimum amount of exercise of 20 minutes of walking, five times per week.

Subjects were observed, and feedback was given, comparing results of individuals with and without the use of Slenderiix and Xceler8, as well as with Slenderiix, Xceler8, foundational Nutritional Supplementation, and a final group who employed all of the above items, plus including Rejuveniix—subjects committed to weekly counseling and instruction with Dr. Hurt. Before and after, and at four-week intervals, subjects’ measurements, weight, and photos were documented before and after a comprehensive blood work panel was drawn and evaluated. This panel consisted of serum inflammatory indicators of fat storage metabolism, known markers that are precursors to diabetes, heart disease, and chronic inflammatory conditions such as cancer. Weight, measurements, and fat store location were documented, reviewed, and compared.

Subjects were stratified randomly into four groups. The Table below outlines the particular products taken by each Group in the initial 4 weeks before the crossover and what products were taken in conjunction with the 1,250-calorie daily consumption.

Subjects were required to consume 200 calories minimum from organic expeller pressed coconut oil in meal preparation, with the option of an additional 50 calories from raw avocado raw nuts or organic cold pressed oils. Finally, subjects were required to exclude any foods not listed in the above table and made a specific note to avoid coffee, mint, or gum products and artificial sweeteners such as sucralose, aspartame, “Splenda” or “Equal,” common to synthetic “diet” or “lite” food replacements. Natural sweeteners, such as erythritol or Stevia liquid, were allowed.

In addition to the products identified above, all subjects were required to eat 1000 calories worth of the following foods in the following quantities:
~Up to two cups of raw, whole, fresh fruit
~Six or more cups of raw, fresh vegetables
~10 to 16 ounces of clean (Free Range, Grass Fed, or Wild) protein

The following table identifies the classifications of foods available for subjects during the program.

Finally, subjects were required to participate in an exercise program. Subjects currently participating in an exercise routine at the onset of the study were allowed to continue with that program at the review of Dr. Hurt. Subjects who were non-exercisers were required to walk for at least 20 minutes a minimum of five days each week.

Results

Of the initial 23 subjects, 19 completed the program. Following a regimen of calorie-limited nutrient-dense diet, appropriate supplementation, hydration, and detoxification with moderate exercise, coupled with the use of specific products, yielded statistically significant results compared to reducing calories alone. The table below provides a summary of the average rate of weight loss per day over time.

After four weeks, subjects in Control Group C were allowed to take Slenderiix. At the crossover, all of the groups using Slenderiix (A, B, D) had lost an average of 13.1 pounds. In each group, 103.4% more weight loss was observed than was experienced in the placebo group within the same time frame. Individuals in the placebo group ate the same meal plan, water, and exercise routines as those of the Slenderiix-using groups. In addition, placebo group subjects were receiving the same nutritional supplementation as the subjects in group A; the only difference in these two groups was between the active Slenderiix for the Group A Subjects and the inactive placebo product for the Control Group C Subjects. Placebo subjects lost an average of only 6.44 pounds in four weeks, employing the same lifestyle efforts, calorie reduction, and timeframe as all other groups.

Within this initial 4-week timeframe, placebo subjects were the only group that reported feeling hungry, fatigue and weakness upon exercise, and difficulty being around food or in the presence of others at mealtimes. By the program's third week, placebo users began to express difficulty continuing to participate in the trial for the remaining nine weeks.

Even though the amount of weight lost within all Slenderiix-using Groups A, B, and D reflected less than 1 pound average variance among the three groups, there was a marked difference in the level of enthusiasm, perception of the ease of the program, increased sense of well-being, and a continual increase in daytime energy and desire to become more active as time went by, within Group D. This group was supported by not only Slenderiix and Xceler8 but all of the Foundational Supplements, as well as Rejuveniix.

Because of the remarkable difference in positive mental attitude coupled with weight loss success, it was decided Groups A, B, and C would, at the crossover time, convert to the Group D regimen for the 8-week duration of the trial.

Even with a relatively small sample, the difference between groups and individual improvement in pre-and post-testing of both subjects were statistically significant. Two-tailed results suggest statistical significance in all groups, except the placebo group, when compared to diet alone.

It is generally maintained that weight loss that is too rapid and sustained over a long period of time is not optimal. Therefore, the rate of weight decline, which is reflective of stabilizing metabolism, is provided in the table below.

Of the two subjects who did not reach their 12-week projected weight goal, one was only 1.6 pounds short of the 25-pound projected possible weight loss for females, and the other was within 3.8 pounds of study projections. It should be noted that the latter subject had exceeded her personal goal of losing 20 pounds. Once personal expectations were fulfilled after the 7th week of the trial, she experienced no additional weight loss in the remaining five weeks of the program. This observation supports the psychological theory that personal expectations play a significant role in weight loss outcomes regarding the possibility of subconscious behaviors sabotaging what is possible. In total, the rate of weight reduction per day experienced by all Slenderiix-using groups consistently exceeded the rate of weight loss compared to a calorie-restricted diet alone.

Biomarkers, which are key indicators of metabolic syndrome, diabetes, cardiac disease, and cancer risk factors, were measured through serum testing both before and after the 12-week trial. Unfortunately, circumstances limited the collection of lab values from every subject, which prevented reporting on every lab value examined. The individuals were to get a selected list of disease markers drawn, known in preventative medicine as indicators of fat storage, obesity, diabetes, and precursors to heart disease and some cancers. Because these labs were to be ordered and collected by each subject’s physician, several physicians declined follow-up labs after the 12-week trial was over. In many cases, this was due to the apparent considerable weight loss, and physicians no longer deemed the labs medically necessary, precluding insurance from covering the cost of the follow-up labs. Due to logistical complications, almost half of the subjects could not provide follow-up lab values for specific tests.

Pre and post-measurements taken from subjects who obtained post-blood work (n=10) found statistically significant differences in each subject on measures generally associated with improved health and markers associated with the disease. The table below provides the paired-t differences between subjects across all groups (excluding placebo). Given the limited sample size related to factorial design, although statistically significant differences in blood markers were found in ALL groups except the placebo group, the interpretive power of such small sample sizes resulted in the exclusion of reporting specific values for this report.

These serum levels are as follows: elevated triglycerides, total cholesterol serum insulin, decreased HDL cholesterol, and glucose tolerance.

Over time, insulin resistance progressively becomes more severe and affects the function of more organs. When serum glucose levels remain elevated, there is an increased likelihood of protein glycosylation and overproduction of free-radical-producing oxidative stress, which have proven association with initial central obesity and eventual atherosclerosis, type II diabetes, heart disease, and cancers. The body’s typical reaction of producing more and more insulin leads to insulin resistance in various locations throughout the body as the disease progresses. In the skin, insulin resistance can be revealed as acne, while insulin resistance in the brain over time becomes Alzheimer’s—recently named Diabetes Type III.

The Serum Measures Chart above reflects that all serum risk factors tested for cardio-metabolic disorders were significantly reduced.

Physical measurements of subjects’ chest, waist, and hips before and after the study reflected that all Slenderiiz-using subjects lost a significant amount of fat in the waist measurement, indicating a decrease in visceral adipose tissue stores and associated mortality risks of central obesity.

Within the first four weeks of the trial, though weight loss was reflected on the scale and visibly in the face and extremities, several placebo subjects did not lose any inches from their waist measurement. One placebo subject, whose total loss goal at the onset of the trial was only 12 lbs, reported initial concern over the loss of significant inches in the chest and extremities without any weight loss in the midsection measures. After the crossover to the active Slenderiix, the subject continued to lose the last few pounds to reach her goal but also noticed a remarkable redistribution of normal body fat to the more desirable female areas as her weight stabilized to a new set point during the remaining few weeks on the active product.

All Slenderiix-using groups reflected significant inches lost in the waist measurement compared to the chest and hips throughout every trial stage. This confirms the ability of the Slenderiiz program to target the release of fat stores in the area of dangerous visceral adipose fat. Although the full extent of the mechanisms that allow this to be possible is yet unknown, serum tests reflect a regain in glycemic control, thus reversing the progression of insulin resistance—first heralded by the visible increase in visceral adipose tissue at the waist measurement—and the pathological risks that would have followed in time.

Typically, belly fat stores are protected by cortisol and other stress hormones in a season of calorie deficit, and studies have shown that these fat stores are typically only released after 90 days on an ultra-low-calorie diet. The results of the Slenderiiz Weight Loss Program suggest a compensatory interaction with these stress-related hormones. The exact mechanism of the action observed is yet undetermined, but it would warrant further study in this area.

Cardio-metabolic Risk Assessors that accompany excess Visceral Adipose Tissue

Typically, as insulin secretion increases, blood triglycerides and glucose levels continue to rise, while HDL levels slowly decrease and VAT begins to accumulate. Since insulin is released in response to too much glucose in the blood, and HbA1c represents the number of hemoglobin molecules that have had glucose molecules attached to them in the bloodstream, these two serum markers typically rise and fall together. Serum insulin levels within study subjects decreased an average of 27.7%, and correlating HbA1c decreased 4.4%.

Even though all cholesterol levels were monitored and improved upon, the cholesterol values that specifically indicate systemic inflammation are now accepted to be most pertinent to reversing the interrelated risks of heart disease and obesity.

The pathology of arterial plaque formation in heart disease has been proven to be caused by several factors that affect the inflammatory response to minor vascular injuries that occur from a cascade of reactive events. Over-production of insulin from sugar and starch consumption, increased platelet adhesion due to omega three fat deficiency with omega 6/9 excess and antioxidant deficiency, and emotional stress, all these sources of oxidative stress contribute to inflammatory pathology. If inflammation is eliminated, arteries are clear, regardless of total cholesterol levels. Across all cholesterol markers, subjects responded with significant improvements in all areas.

The cholesterol fraction indicating potential endothelial inflammatory damage is called Very Low-Density Lipoproteins (VLDL). When cholesterol is oxidized into VLDL due to excessive free radical production, it means an insufficient amount of antioxidants available within the body. VLDL can be significantly reduced by supplementing adequate vitamins, minerals, and antioxidants by modulating increases beyond standard dosing appropriate to the individual's stress level. This inflammatory marker, VLDL, was significantly reduced.

The National Institutes of Health funded the VITAL study to assess the effect of vitamin D and omega-3 supplementations on preventing cancer and heart disease. (23) This large-scale randomized trial also correlated to fasting insulin, glucose, altered cholesterol ratios, and the prevalence of metabolic syndrome. Findings proved that the lower the serum vitamin D, the more prevalent these inflammatory makers are for insulin resistance, progressing to metabolic syndrome. Increasing serum 25(OHD) is associated with a responsive lowering of VAT, triglycerides, and triglyceride/HDL-cholesterol ratio. Within this trial period, subjects' serum vitamin D increased an overage of 15.7% overall, raising serum levels of 9 out of 10 subjects to reflect an optimal range of 40-69 ng/ml and the remaining subject at 39.10 ng/ml. Due to the seasonality of the trial, beginning in fall and ending mid-winter, these results are impressive, considering vitamin D levels typically plummet in winter months and fat stores simultaneously increase.

Higher levels of Highly Sensitive C-reactive protein are linked to higher occurrences of sudden cardiac death, strokes, peripheral artery disease, and myocardial infarction. HS-CRP is an inflammatory particle produced by the liver in response to stressors. Trial subjects averaged a 24% reduction in HS-CRP.

Since about 50% of all heart attacks and strokes affect people with normal total cholesterol levels, anti-aging medicine specialists now look to a combination assessment of the inflammatory HS-CRP along with the ratio of Triglycerides (TG) to High-Density Lipoprotein (HDL) cholesterol to offer more effective proactive approaches to risk assessment. (22, 25, 26) As most triglycerides in the blood are indicative of carbohydrates that have been converted into fat that will be explicitly stored in the visceral adipose tissue area, reducing serum levels of triglycerides and comparing these levels to a sufficient quantity of HDL is a significant indicator of the degree of disease pathology, to identify the patient’s place on the continuum between insulin resistance and metabolic syndrome. (24)

Data from the Third National Health and Nutrition Examination Survey (NHANES III) indicated that the most frequently noted serum markers among overweight and obese adolescents are high TG (25–30% of adolescents) and low HDL cholesterol levels (40–50% of adolescents). (26)

The table below reflects the TG/HDL Ratio improvement results within the 12 weeks.

The ratio of TG to HDL is a reliable indicator of the extent of insulin resistance in cholesterol metabolism. (27) Subjects within the Slenderiix Clinical Trial produced a 41% reduction in Triglyceride to HDL ratios, significantly reducing serum-defined insulin resistance and cardio-metabolic risk.

Conclusions

Subjects taking Slenderiiz also reported increased energy and sense of well-being compared to individuals on diet alone. Subjects taking a placebo reported significant hunger, low energy, intolerance to exercise, in-between meal headaches, and difficulty around others eating food, more than all other groups. Subjects who used all ARIIX foundational nutrients, Slenderiiz and Rejuveniix, reported the greatest amount of energy and focus and had the highest rate of weight loss in all groups. Unlike any other group, no single subject taking Slenderiiz and Rejuveniix combined reported mild to moderate headaches, fatigue, and symptoms of detoxification or withdrawal from processed foods within the first week. Further study on these self-reported benefits of Rejuveniix is warranted.

Typical of overweight individuals, most subjects showed elevated levels of HS-CRP, triglycerides, VLDL cholesterol, total cholesterol, fasting insulin, serum glucose, HbA1C, and depressed HDL and vitamin D levels at baseline. Statistically significant improvement occurred for all subjects taking ARIIX Products, in addition to diet and exercise only, across all measures. These results suggest metabolic recovery and turning toward systemic homeostasis, thereby decreasing the risk factors for the secondary diseases of obesity, heart disease, and cancer. All subjects on ARIIX products with initially established inflammatory markers for heart disease, excessive systemic inflammation, and oxidative stress showed significant improvements, indicating improved health and metabolism.

Triglyceride levels of all subjects taking ARIIX products significantly improved. The average subject experienced a statistically significant decrease in triglyceride levels of (p<.0005). According to Anti-aging medicine specialists, the single most important factor to increase life expectancy is the ability to increase HDL cholesterol as high above 40 ng/dL as possible. Within the 12-week period, the average increase in HDL cholesterol of 15% brought 90% of subjects within the optimal range in all ARIIX groups. This reflects a significant (p<.0005) reduction in the risk of all causes of disease-related death.

Approximately 90% of subjects achieved their weight loss objective during the study compared to none of the control group subjects. This finding suggests that the faster the rate of weight loss, with less physical discomfort, the higher the compliance rate to maintain a weight loss program.

Finally, the subjects' physical, psychological, and emotional changes were observed. Subjects losing weight often comment on increased energy, confidence, and enthusiasm to continue their new habits as a continued lifestyle. The psychological impact of being empowered with the knowledge and ability for individuals to create a metabolic shift in a completely new direction in such a short period of time was transformational for all test subjects taking ARIIX products rather than calorie reduction alone.

Additional longitudinal studies would prove beneficial in evaluating subjects’ conformity to the consumption of metabolic supportive supplements, modified diet, and moderate exercise adhered to during the trial.

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